[提要] 當T2DM進展到一定程度，需啟用胰島素治療。基礎和預混胰島素是常用的胰島素類型。短期和長期的臨床研究均證實，采用預混或基礎胰島素起始胰島素治療均可有效改善血糖，達到相類似的臨床效果。臨床試驗證明，預混胰島素強化治療方案和基礎餐時治療方案療效相當。在臨床治療方案的選擇上，應重視個體化治療，選擇符合患者臨床特點的治療方案。

[關鍵詞]糖尿病，2型;預混胰島素;基礎胰島素; 個體化治療，臨床試驗

[Summary] Insulin therapy needs to be initiated when type 2 diabetes progresses. Basal and premix insulin are the commonly used insulin formulations. Short- and long- term clinical studies have demonstrated that treatment with basal or premix insulin as insulin initiation can similarly effectively improve glycaemic control. In addition, clinical researches have shown that the therapeutic effect of theintensification treatment with basal or premix insulin was comparable. The individualized treatment that is customised with the clinical characteristics of the patientsis important when considering the anti-diabetic therapies.

[Key words] Diabetes mellitus, type 2 ; Premixed insulin ;Basal insulin; Individualized therapy; Clinical trial.